Background: The value of magnetic resonance imaging (MRI), contrast-enhanced ultrasound (CEUS), and the combination\nof CEUS and MRI (CCWM) for the diagnosis of periampullary space-occupying lesions (PSOL) was investigated.\nMethods: A total of 102 patients diagnosed with PSOLs by surgery or biopsy were recruited retrospectively. The\nsensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and accuracy of MRI, CEUS, and\nCCWM were analyzed.\nResults: MRI, CEUS, and CCWM allowed for the accurate detection of 91.17, 92.15, and 99.01% of PSOLs, respectively.\nThe specificity, PPV, and accuracy of CCWM were significantly different from MRI and CEUS (p < 0.05). However, there\nthe sensitivity and NPV were not significantly different among the three diagnostic technologies. In addition, the\nspecificity, PPV, and accuracy were not significantly different between MRI and CEUS (all p > 0.05).\nConclusions: CCWM is valuable for differentiating benign and malignant PSOL, which provides important guiding\nsignificances for the clinic.
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